The crazy toad Manifesto is a collective work, led by Thanh Nghiem and Cedric Villani. In April 2017, 34 people from 22 to to 79 years old, mixing skills, personalities and cultures, spent a week together South of France, to start the basics of a Manifesto. It is a book and a philosophy, outlining the challenges faced in our world in transition and offering solutions, through 9 circles and 3 principles: Neurodiversity, Europe, Digital Era, Cultural Diversity, Human Collaboration, Europe, Science, Big Data, and Ethique and Integrity.